Chemagis' Active Pharmaceutical Ingredients [API] and Finished Dosage Forms [FDF]

Fluticasone Propionate

Antiinflammatory, Antiallergic agent

Availability

API

Molecular Formula

C25H31F3O5S

IUPAC Nomenclature

(6, 11, 16, 17)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo -17-(1-oxopropoxy) androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl)ester)

Therapeutic Category

Anti-inflammatory, Antiallergenic agent

CAS Number

80474-14-2

Presentation

Dry powder inhaler (DPI): 50/100/250/500 mcg/blister
Metered dose inhaler: 25/50/125/250 mcg/dose
Metered nasal spray: 0.05% w/w Cream: 0.05% Ointment: .005%

Brand Name

Cutivate, Flixonase, Flixotide, Flonase, Flutivate, Fluvent, Accuhaler

Inventor

Glaxo

Patents

Method of isolating a Fluticasone intermediate
Salt intermediates preparation process
Fluticasone spray-dried preparation
Fluticasone intermediate polymorphs

US 6,747,163
US2004/0116396
US2006/0009435
US2006/0019937

API and FDF Products